Boston Detective Jane Rizzoli is on the case of a big game hunter found dead in his apartment, alone with the body of a beautiful white snow leopard he had recently been commissioned to procure and stuff for a high-profile museum in the area. Medical examiner Maura Isles connects the case to a number of seemingly unrelated deaths where the victims have all been found hanging upside down, the hallmark of a leopard's kill. Rizzoli follows the puzzling trail of clues all the way to Botswana, where she uncovers the unsolved mystery of a deadly camping safari four years prior. When she realises the two cases are connected, Rizzoli must track down the sole survivor of the tragic trip to discover who – or what – is behind these gruesome deaths.