Set in glamorous New York City, four women stay close as they strive for success in the business world. Affectionately known as the Cashmere Mafia, they rely on each other for support in both their careers and their often-tumultuous personal relationships. Publisher Mia (Lucy Liu), CEO Juliet (Miranda Otto), top business executive Zoe (Frances O'Conner) and key marketing executive Caitlin (Bonnie Somerville) are bright, driven and dedicated, supporting each other through rocky marriages, rival colleagues, kids' recitals and the hunt for the perfect loft. Their ambition comes with a price - although they consistently outpace their male colleagues and husbands in salary and title, they must watch out for scheming rivals, eager to bring them down. But how better to climb to the top of the corporate ladder than with your buddies at your side?