Three girls from Townsville, USA, team-up to fight crime before bedtime.

The city of Townsville - an average metropolis plague by an above average number of below average ne'er-do-wells. That is until Professor Utonium mixes up a special concoction of sugar, spice and everything nice, plus an accidental does of Chemical X creating the precious and precocious Powerpuff Girls! Mojo Jojo, Fuzzy Lumpkins, Him, and the other villains better watch their backs because the girls are ready to save the day, as long as it's before bedtime. The first season finds the trio exterminating Roach Coach, crashing Boogie Man's ball, and walking on thin ice while mastering their own powers. You up-to-no-goody two shoes better watch out, because the Powerpuff Girls have arrived!